Copper-catalyzed arylation of heterocycle C-H bonds

被引：460

作者：

Do, Hien-Quang ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Houston, TX 77204 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 41期

关键词：

D O I：

10.1021/ja075802+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert -butoxide base, aryl iodide coupling partner, and copper iodide catalyst.

引用

页码：12404 / +

页数：3

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