Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism

被引：43

作者：

Raja, SM ^{[1
]}

Metkar, SS ^{[1
]}

Froelich, CJ ^{[1
]}

机构：

[1] Evanston NW Healthcare Res Inst, Dept Med, Evanston, IL 60201 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(03)00111-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular details of cytotoxic granule-mediated apoptosis have been gleaned from the study of the effects of isolated granzymes and perforin on target cells. Recent evidence indicates that the physiological apoptosis-inducing form is a multi-component macro-complex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteoglycan, serglycin.

引用

页码：528 / 532

页数：5

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