123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder

被引：102

作者：

Miyamoto, Tomoyuki ^{[1
]}

Miyamoto, Masayuki ^{[1
]}

Suzuki, Keisuke ^{[1
]}

Nishibayashi, Momoka ^{[1
]}

Iwanami, Masaoki ^{[1
]}

Hirata, Koichi ^{[1
]}

机构：

[1] Dokkyo Med Univ, Sch Med, Dept Neurol, Ctr Sleep Med, Mibu, Tochigi 3210293, Japan

来源：

SLEEP | 2008年 / 31卷 / 05期

关键词：

REM sleep behavior disorder (RBD); Parkinson disease (PD); synucleinopathies; Lewy body disease (LBD); cardiac I-123-MIBG scintigraphy;

D O I：

10.1093/sleep/31.5.717

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: RBD is considered to be a manifestation of an evolving synucleinopathy, such as Parkinson disease (PD), dementia of Lewy bodies (DLB), and multiple system atrophy (MSA). We tested whether the degree of accumulation of cardiac I-123-MIBG scintigraphy can distinguish the clinical syndromes associated with Lewy body-related disease from the syndrome of PSP (a tauopathy) and MSA. Design: Cross-sectional. Setting: University-based sleep disorders laboratory. Patients: Subjects comprised 95 patients (31, idiopathic RBD; 26, PD; 10, MSA; 6, DLB; 13, progressive supranuclear palsy [PSP]) and 9 control subjects. Intervention: To compare tracer uptake of cardiac I-123-MIBG between idiopathic RBD, PD, MSA, DLB, and PSP and control subjects. Measurements and Results: Cardiac I-123-MIBG accumulation was evaluated by the heart/mediastinum (H/M) ratio. Mean value of the H/M ratio (early, delayed) was significantly reduced in patients with idiopathic RBD compared to MSA patients, PSP patients, control subjects (P < 0.001 in each group) and PD patients in early images (P < 0.05). There was a correlation between the H/M ratio and disease duration in the idiopathic RBD group. ROC analysis revealed that an H/M cut-off value of 1.9 was useful for differentiating RBD from MSA and PSP as well as distinguishing control subjects from those with RBD in both early and delayed images. Conclusion: Cardiac I-123-MIBG findings are similar among idiopathic RBD and the syndromes of PD and DLB, but differ from those of PSP and MSA.

引用

页码：717 / 723

页数：7

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