Raman detection of pigments in the human retina

被引：7

作者：

Gellermann, W ^{[1
]}

Yoshida, MD ^{[1
]}

McClane, RW ^{[1
]}

Balashov, N ^{[1
]}

Bernstein, PS ^{[1
]}

机构：

[1] Univ Utah, Dept Phys, Salt Lake City, UT 84112 USA

来源：

OPTICAL BIOPSY II, PROCEEDINGS OF | 1998年 / 3250卷

关键词：

Raman scattering; Resonance Raman Spectroscopy; retina macula; carotenoids; age-related macular degeneration;

D O I：

10.1117/12.305368

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We have used resonance Raman scattering as a non-invasive optical technique to measure the concentration of caratenoid pigments in the human retina The technique is highly sensitive and specific, and signal strength scales linearly with actual macular carotenoid content as measured by high-pressure liquid chromatography. This will facilitate studies of carotenoid distributions and their role in degenerative diseases of the eye and may allow for the rapid screening of carotenoid levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness in the elderly in the United States.

引用

页码：8 / 17

页数：10