NADPH oxidases in cardiovascular disease

被引：227

作者：

Brandes, Ralf P. ^{[1
]}

Weissmann, Norbert ^{[2
]}

Schroder, Katrin ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Kardiovaskulare Physiol, Fachbereich Med, Frankfurt, Germany

[2] Univ Giessen, Lung Ctr, ECCPS, Giessen, Germany

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2010年 / 49卷 / 05期

关键词：

NADPH oxidase; Nox proteins; Redox regulation; Vascular disease; Hypertension; Arteriosclerosis; Angiogenesis; SMOOTH-MUSCLE-CELLS; PROTEIN-KINASE-C; NITRIC-OXIDE SYNTHASE; SUPEROXIDE ANION PRODUCTION; OXYGEN SPECIES PRODUCTION; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MESSENGER-RNA EXPRESSION; LOW-DENSITY-LIPOPROTEIN; NOX4 NAD(P)H OXIDASE; MICROVASCULAR ENDOTHELIAL-CELLS;

D O I：

10.1016/j.freeradbiomed.2010.04.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including ischemia-reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and hypertrophy NADPH meioses of the Nox family are differentially expressed in the cardiovascular system, induced or activated by cardiovascular risk factors and importantly contribute to the oxidative burden of vascular diseases Moreover, NADPH oxidase-derived ROS are important signaling molecules under physiological conditions In this article, the current knowledge on NADPH oxidase expression, activation, and signaling in the cardiovascular system as well as the impact of risk factors on the function of these proteins will be reviewed Finally, the contribution of NADPH oxidases to the predominant cardiovascular diseases will be discussed (C) 2010 Elsevier Inc All rights reserved

引用

页码：687 / 706

页数：20

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