Cytoprotective effects of chalcones from Zuccagnia punctata and melatonin on the gastroduodenal tract in rats

被引：24

作者：

de la Rocha, N

María, AOM

Gianello, JC

Pelzer, L

机构：

[1] Univ Nacl San Luis, Catedra Farmacol, Fac Quim Bioquim & Farm, RA-5700 San Luis, Argentina

[2] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Dept Quim Organ, San Luis, Argentina

来源：

PHARMACOLOGICAL RESEARCH | 2003年 / 48卷 / 01期

关键词：

chalcones; melatonin; Zuccagnia sp; cytoprotection; gastric; duodenal;

D O I：

10.1016/S1043-6618(03)00063-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 2',4'-dihydroxychalcone and 2,4'-dihydroxy-3-methoxychalcone from Zuccagnia punctata Cav. (Fabaceae) and melatonin administration on ethanol-induced gastroduodenal injury were investigated in rats. Both chalcones showed significant preventive effects in treatment with melatonin previous to the necrotising agent. These effects could be due, in part, to the radical scavenging activity of the melatonin. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：97 / 99

页数：3

共 14 条

[1] ON THE PRIMARY FUNCTIONS OF MELATONIN IN EVOLUTION - MEDIATION OF PHOTOPERIODIC SIGNALS IN A UNICELL, PHOTOOXIDATION, AND SCAVENGING OF FREE-RADICALS [J].