Comparative anti-proliferative activity of some new 2-(arylazo) phenolate-palladium (II) complexes and cisplatin against some human cancer cell lines

被引：14

作者：

Banerjee, P. ^{[1
]}

Majumder, P. ^{[2
]}

Halder, S. ^{[2
]}

Drew, M. G. B. ^{[3
]}

Bhattacharya, S. ^{[2
]}

Mazumder, S. ^{[1
]}

机构：

[1] Univ Calcutta, Dept Biochem, Kolkata 700073, W Bengal, India

[2] Jadavpur Univ, Dept Chem, Inorgan Chem Sect, Kolkata, India

[3] Univ Reading, Dept Chem, Reading RG6 2AD, Berks, England

来源：

FREE RADICAL RESEARCH | 2015年 / 49卷 / 03期

关键词：

2-(Arylazo) phenolate complexes of palladium; human lung cancer cell line; ROS; caspase-3; INDUCED APOPTOSIS; BAX TRANSLOCATION; ANTICANCER DRUGS; CYTOCHROME-C; IN-VITRO; ACTIVATION; MITOCHONDRIA; PD(II); PT(II); PROLIFERATION;

D O I：

10.3109/10715762.2014.998665

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study, we report the synthesis of four 2-(arylazo) phenol-Pd(II) complexes and their anti-proliferative property against the human lung cancer (A549), cervical cancer (HeLa), and ovarian teratocarcinoma (PA-1) cell lines with cisplatin as the gold standard. One of the complexes, [Pd(L-2)(2)], induced robust apoptosis in all the chosen cells, as revealed by annexin-V-positive/propidium iodide dual staining, increased sub-G1 cell cycle population, and significant morphological changes in the treated cells. The Pd complex inflicted mitochondrial dysfunction leading to mitochondrial membrane potential loss, reactive oxygen species generation and release of cytosolic cytochrome c that activated caspase-9 and caspase-3 proteins which finally caused programmed cell death.

引用

页码：253 / 268

页数：16

共 49 条

[1]

Platinum group antitumor chemistry: Design and development of new anticancer drugs complementary to cisplatin [J].