Two New Lignans from the Roots of Pulsatilla koreana

被引：21

作者：

Cuong, To Dao ^{[2
]}

Hung, Tran Manh ^{[2
]}

Kim, Jin-Cheol ^{[3
]}

Huh, Jung-Im ^{[3
]}

Kwack, Seung Jun ^{[4
]}

Kang, Tae Suk ^{[4
]}

Kim, Jung Hee ^{[5
]}

Jang, Han Su ^{[6
]}

Choi, Jae Sue ^{[7
]}

Lee, Hyeong-Kyu ^{[5
]}

Bae, KiHwan ^{[1
]}

Min, Byung Sun ^{[2
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, Gyeongbuk, South Korea

[3] Korea Res Inst Chem Technol, Taejon, South Korea

[4] Natl Inst Toxicol Res, Seoul, South Korea

[5] Korea Res Inst Biosci & Biotechnol, Taejon, South Korea

[6] Gyeongbuk Inst Bio Ind, Gyeongbuk, South Korea

[7] Pukyong Natl Univ, Fac Food Sci & Biotechnol, Pusan, South Korea

来源：

PLANTA MEDICA | 2011年 / 77卷 / 01期

关键词：

Pulsatilla koreana; Ranunculaceae; lignan; anticomplement activity; ANTI-COMPLEMENT ACTIVITY; ANTICOMPLEMENTARY ACTIVITY; ANTIOXIDANT ACTIVITY; TRITERPENOIDS; CONSTITUENTS; MANDSHURICA; FLAVONOIDS; CHINENSIS; SAPONINS; JAPONICA;

D O I：

10.1055/s-0030-1250122

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new lignans, (2R,3R)-2 beta-(4 ''-hydroxy-3 ''-methoxybenzyl)-3 alpha-( 4'-hydroxy-3'-methoxybenzyl)-gamma-butyrolactone 2-O-(beta-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetra-hydro-3,6,7-trihydroxy-1-(3', 4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 mu M, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 mu M, respectively.

引用

页码：66 / 69

页数：4

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