Barreling through the outer membrane

被引：24

作者：

Matouschek, A

Glick, BS

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

[2] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 04期

关键词：

D O I：

10.1038/86140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein translocation channel of the outer mitochondrial membrane is thought to be a rigid P-barrel, Newly synthesized membrane proteins apparently do not escape laterally from this channel into the lipid bilayer, but must insert into the outer membrane from the aqueous phase. A study on the biogenesis of the mitochondrial outer membrane translocation machinery now shows that the subunit forming the protein import channel is first translocated across the outer membrane and then reinserted.

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页码：284 / 286

页数：3

相关论文

共 11 条

[1] CYTOCHROMES-C1 AND CYTOCHROMES-B2 ARE SORTED TO THE INTERMEMBRANE SPACE OF YEAST MITOCHONDRIA BY A STOP-TRANSFER MECHANISM [J].

GLICK, BS ;

BRANDT, A ;

CUNNINGHAM, K ;

MULLER, S ;

HALLBERG, RL ;

SCHATZ, G .

CELL, 1992, 69 (05) :809-822

[2]

Johnson DJ, 1999, ARCH CLIN NEUROPSYCH, V14, P799

[3] Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex [J].

Krimmer, T ;

Rapaport, D ;

Ryan, MT ;

Meisinger, C ;

Kassenbrock, CK ;

Blachly-Dyson, E ;

Forte, M ;

Douglas, MG ;

Neupert, W ;

Nargang, FE ;

Pfanner, N .

JOURNAL OF CELL BIOLOGY, 2001, 152 (02) :289-300

[4] The preprotein translocation channel of the outer membrane of mitochondria [J].

Künkele, KP ;

Heins, S ;

Dembowski, M ;

Nargang, FE ;

Benz, R ;

Thieffry, M ;

Walz, J ;

Lill, R ;

Nussberger, S ;

Neupert, W .

CELL, 1998, 93 (06) :1009-1019

[5] IMPORT OF CYTOCHROME-C HEME LYASE INTO MITOCHONDRIA - A NOVEL PATHWAY INTO THE INTERMEMBRANE SPACE [J].

LILL, R ;

STUART, RA ;

DRYGAS, ME ;

NARGANG, FE ;

NEUPERT, W .

EMBO JOURNAL, 1992, 11 (02) :449-456

[6] Detection of likely transmembrane beta-strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler [J].

Mannella, CA ;

Neuwald, AF ;

Lawrence, CE .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1996, 28 (02) :163-169

[7] Signal anchor sequence insertion into the outer mitochondrial membrane - Comparison with porin and the matrix protein targeting pathway [J].

Millar, DG ;

Shore, GC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) :25823-25829

[8] Multistep assembly of the protein import channel of the mitochondrial outer membrane [J].

Model, K ;

Meisinger, C ;

Prinz, T ;

Wiedemann, N ;

Truscott, KN ;

Pfanner, N ;

Ryan, MT .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (04) :361-370

[9] IMPORT PATHWAYS OF PRECURSOR PROTEINS INTO MITOCHONDRIA - MULTIPLE RECEPTOR-SITES ARE FOLLOWED BY A COMMON MEMBRANE INSERTION SITE [J].

PFALLER, R ;

STEGER, HF ;

RASSOW, J ;

PFANNER, N ;

NEUPERT, W .

JOURNAL OF CELL BIOLOGY, 1988, 107 (06) :2483-2490

[10] Signal sequence recognition in posttranslational protein transport across the yeast ER membrane [J].

Plath, K ;

Mothes, W ;

Wilkinson, BM ;

Stirling, CJ ;

Rapoport, TA .

CELL, 1998, 94 (06) :795-807