The master regulators of allergic inflammation: dendritic cells in Th2 sensitization

被引：75

作者：

Eisenbarth, SC ^{[1
]}

Piggott, DA ^{[1
]}

Bottomly, K ^{[1
]}

机构：

[1] Yale Univ, Dept Immunobiol, New Haven, CT 06510 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of Th2 responses to inhaled proteins represents a malfunction of the adaptive immune system in that protein antigens are not microbial in nature and should not elicit an adaptive immune reaction. This derailing of the immune system may result from false alarms generated by the innate immune system, resulting in unexpected dendritic cell (DC) maturation after exposure to allergens. Conditions in the local microenvironment during DC maturation may also result in the preferential induction of Th2 responses. Recent progress has been made in our understanding of the role of DCs in both Th2 sensitization to aeroallergens and the regulation of Th2 and Th1 immunity.

引用

页码：620 / 626

页数：7

共 56 条

[51] Cutting edge: Role of IL-27/WSX-1 signaling for induction of T-Bet through activation of STAT1 during initial Th1 commitment [J].