Epigenetics of hypertension in pregnancy

被引：12

作者：

Arngrímsson, R ^{[1
]}

机构：

[1] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland

来源：

NATURE GENETICS | 2005年 / 37卷 / 05期

关键词：

D O I：

10.1038/ng0505-460

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Maternal hypertension in pregnancy is a genetically complex condition originating in the placenta. Because of imprinting, only the maternal copy of the gene encoding STOX1 is expressed in invasive placental extravillous trophoblasts. Therefore, maternally inherited missense mutations affecting this putative DNA-binding protein predispose to preeclampsia, possibly by interfering with differentiation of the trophoblast cells.

引用

页码：460 / 461

页数：3

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