Interaction of indomethacin with a new penetration enhancer, dodecyl 2-(N,N-dimethylamino)propionate (DDAIP): Its effect on transdermal delivery

被引：9

作者：

Buyuktimkin, S ^{[1
]}

Buyuktimkin, N ^{[1
]}

Rytting, JH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 127卷 / 02期

关键词：

indomethacin; dodecyl; 2-(N; N-dimethylamino)propionate; azone; interaction; UV; IR; H-1-NMR; C-13-NMR; differential scanning calorimetry; transdermal delivery; shed snake skin;

D O I：

10.1016/0378-5173(96)80691-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The new biodegradable penetration enhancer DDAIP (dodecyl 2-(N,N-dimethylamino)propionate) shows a striking enhancement of the acidic drug indomethacin through shed snake skin. This enhancement appears-to be due partially to some interaction between the drug and the enhancer. This interaction was examined using UV, IR, H-1- and C-13-NMR spectrometry and differential scanning calorimetry (DSC). The existence of preferential hydrogen bonding between the carboxylic acid group of indomethacin and the tertiary amine group of the enhancer and a dipole-dipole interaction was demonstrated.

引用

页码：245 / 253

页数：9

共 22 条

[1] INTERACTION OF PERCUTANEOUS-ABSORPTION ENHANCER WITH STRATUM-CORNEUM OF HAMSTER-CHEEK POUCH - AN ELECTROPHYSIOLOGICAL STUDY [J].