The Newfoundland population: a unique resource for genetic investigation of complex diseases

被引：70

作者：

Rahman, P

Jones, A

Curtis, J

Bartlett, S

Peddle, L

Fernandez, BA

Freimer, NB

机构：

[1] Mem Univ Newfoundland, Dept Med, St Johns, NF, Canada

[2] Mem Univ Newfoundland, Dept Genet, St Johns, NF, Canada

[3] Mem Univ Newfoundland, Dept Hist, St Johns, NF, Canada

[4] Mem Univ Newfoundland, Dept Pediat, St Johns, NF A1C 5S7, Canada

[5] Newfound Genom, St Johns, NF, Canada

[6] Ctr Neurobehav Genet, St Johns, NF, Canada

[7] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90024 USA

[8] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90024 USA

来源：

HUMAN MOLECULAR GENETICS | 2003年 / 12卷

关键词：

D O I：

10.1093/hmg/ddg257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The population of the province of Newfoundland and Labrador is genetically isolated. This isolation is evidenced by an overabundance of several monogenic disorders. The Newfoundland population, like that of other isolates, is now the focus of interest for identification of genes implicated in common diseases. However, the utility of such populations for this purpose remains unproven. In this paper, we review the current genetic architecture of the province, with respect to geographic isolation, homogeneity, founder effect, genetic drift and extended linkage disequilibrium. Based on these factors, we propose that the population of Newfoundland offers many advantages for genetic mapping of common diseases, compared with admixed populations, and even compared with other isolates.

引用

页码：R167 / R172

页数：6

共 42 条

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