Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice

被引：42

作者：

Leemans, JC

Heikens, M

van Kessel, KPM

Florquin, S

van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Eijkman Winkler Inst, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2003年 / 10卷 / 05期

关键词：

D O I：

10.1128/CDLI.10.5.950-953.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.

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页码：950 / 953

页数：4

相关论文

共 34 条

[1] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Mark, MR ;

Suggett, S ;

Devaux, B ;

Radolf, JD ;

Klimpel, GR ;

Godowski, P ;

Zychlinsky, A .

SCIENCE, 1999, 285 (5428) :736-739

[2] Synergy between TLR2 and TLR4: A safety mechanism [J].

Beutler, E ;

Gelbart, T ;

West, C .

BLOOD CELLS MOLECULES AND DISEASES, 2001, 27 (04) :728-730

[3] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[4]

Cowdery J, 1996, J IMMUNOL, V156, P4570

[5] THE CELL-WALL COMPONENTS PEPTIDOGLYCAN AND LIPOTEICHOIC ACID FROM STAPHYLOCOCCUS-AUREUS ACT IN SYNERGY TO CAUSE SHOCK AND MULTIPLE ORGAN FAILURE [J].

DEKIMPE, SJ ;

KENGATHARAN, M ;

THIEMERMANN, C ;

VANE, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10359-10363

[6] MD-2 enables toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to gram-positive and gram-negative bacteria and their cell wall components [J].

Dziarski, R ;

Wang, QL ;

Miyake, K ;

Kirschning, CJ ;

Gupta, D .

JOURNAL OF IMMUNOLOGY, 2001, 166 (03) :1938-1944

[7]

Favero MS, 1996, AM J INFECT CONTROL, V24, P380

[8] Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia [J].

Greenberger, MJ ;

Strieter, RM ;

Kunkel, SL ;

Danforth, JM ;

Laichalk, LL ;

McGillicuddy, DC ;

Standiford, TJ .

JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01) :159-165

[9] A Toll-like receptor recognizes bacterial DNA [J].

Hemmi, H ;

Takeuchi, O ;

Kawai, T ;

Kaisho, T ;

Sato, S ;

Sanjo, H ;

Matsumoto, M ;

Hoshino, K ;

Wagner, H ;

Takeda, K ;

Akira, S .

NATURE, 2000, 408 (6813) :740-745

[10]

Hirschfeld M, 1999, J IMMUNOL, V163, P2382

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