Early metabolic derangements in daughters of women with polycystic ovary syndrome

Context: Polycystic ovary syndrome ( PCOS) is a familial endocrine-metabolic dysfunction, increasingly recognized in adolescent girls with hyperandrogenism. However, it is difficult to establish whether the metabolic abnormalities described in PCOS are present before the onset of hyperandrogenism. In children, a strong association of adiponectin levels with metabolic parameters of insulin resistance has been described. Objective: The objective of the study was to evaluate adiponectin serum concentrations and metabolic parameters in prepubertal and pubertal daughters of women with PCOS to identify girls with increased metabolic risk. Design: Fifty-three prepubertal and 22 pubertal ( Tanner stages II-V) daughters of PCOS women (PCOSd) and 32 prepubertal and 17 pubertal daughters of control women ( Cd) were studied. In both groups, an oral glucose tolerance test was performed with measurement of glucose and insulin. Adiponectin, leptin, C-reactive protein, SHBG, sex steroids, and lipids were determined in the fasting sample. Results: Both groups had similar chronological ages, body mass index SD score, and Tanner stage distribution. In the prepubertal girls, 2-h insulin was higher ( P = 0.023) and adiponectin levels were lower ( P = 0.004) in the PCOSd group, compared with the Cd group. In the pubertal girls, triglycerides ( P = 0.03), 2-h insulin ( P = 0.01), and serum testosterone concentrations were higher ( P = 0.012) and SHBG lower ( P = 0.009) in PCOSd, compared with Cd, but adiponectin levels were similar in both groups. Conclusions: Some of the metabolic features of PCOS are present in daughters of PCOS women before the onset of hyperandrogenism. Adiponectin appears to be one of the early markers of metabolic derangement in these girls.