Structure of complement receptor 2 in complex with its C3d ligand

被引：127

作者：

Szakonyi, G

Guthridge, JM

Li, DW

Young, K

Holers, VM

Chen, XJS ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Biochem & Mol Genet, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Med, Denver, CO 80262 USA

[3] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Immunol, Denver, CO 80262 USA

来源：

SCIENCE | 2001年 / 292卷 / 5522期

关键词：

D O I：

10.1126/science.1059118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 Ligands include complement C3d and Epstein-Barr virus glycoprotein 350/ 220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms, The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing, These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

引用

页码：1725 / 1728

页数：4

共 29 条

[1] Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen [J].