New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

被引：12

作者：

Baro, Cristina ^{[1
,2
]}

Salido, Marta ^{[1
,2
]}

Espinet, Blanca ^{[1
]}

Astier, Laura ^{[1
]}

Domingo, Alicia

Granada, Isabel ^{[4
]}

Milla, Fuensanta ^{[4
]}

Carrio, Ana ^{[5
]}

Costa, Dolors ^{[5
]}

Luno, Elisa ^{[6
]}

Hernandez, Jesus Ma ^{[7
]}

Campo, Elias ^{[5
]}

Florensa, Lourdes ^{[1
]}

Ferrer, Ana ^{[1
]}

Salar, Antonio ^{[3
]}

Bellosillo, Beatriz ^{[1
]}

Besses, Carles ^{[3
]}

Serrano, Sergi ^{[1
]}

Sole, Francesc ^{[1
]}

机构：

[1] URTTS IMAS IMIM, Serv Patol, Lab Citogenet & Biol Mol, URNHE IMAS IMIM,Hosp Mar,Lab Citol Hematol, Barcelona 08003, Spain

[2] Univ Autonoma Barcelona, Fac Biociencies, Unitat Antropol Biol, Dept Biol Anim Vegetal & Ecol, Bellaterra, Spain

[3] URNHE IMAS IMIM, Hosp Mar, Serv Hematol Clin, Barcelona, Spain

[4] Hosp Badalona Germans Trias & Pujol, Serv Hematol, Badalona, Spain

[5] Hosp Clin Barcelona, Unitat Hematopatol, Barcelona, Spain

[6] Hosp Univ Cent Asturias, Serv Hematol, Oviedo, Spain

[7] Univ Salamanca, CIC, Ctr Invest Canc,Hosp Clin Univ,Serv Hematol, E-37008 Salamanca, Spain

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 05期

关键词：

cytogenetics; SKY; FISH; splenic marginal zone lymphoma;

D O I：

10.1016/j.leukres.2007.09.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：727 / 736

页数：10

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