共 65 条
Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability
被引:64
作者:

Huang, AM
论文数: 0 引用数: 0
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机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA

Montagna, C
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机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA

Sharan, S
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机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA

Ni, YJ
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机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA

Ried, T
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机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA

Sterneck, E
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h-index: 0
机构: Regulat Cell Growth Lab, Frederick, MD 21702 USA
机构:
[1] Regulat Cell Growth Lab, Frederick, MD 21702 USA
[2] NCI, Genet Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源:
关键词:
C/EBP;
tumor suppressor;
mouse embryo fibroblast;
chromosomal rearrangements;
genomic instability;
D O I:
10.1038/sj.onc.1207285
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The transcription factor CCAAT/enhancer binding protein delta (Cebpd, also known as C/EBPdelta, CRP3, CELF, NF-IL6beta) is implicated in diverse cellular functions such as the acute phase response, adipocyte differentiation, learning and memory, and mammary epithelial cell growth control. Here, we report that lack of Cebpd causes genomic instability and centrosome amplifications in primary embryonic fibroblasts derived from 129S1 mice. Upon spontaneous immortalization, Cebpd-deficient fibroblasts acquire transformed features such as impaired contact inhibition and reduced serum dependence. These data identify a novel role for Cebpd in the maintenance of chromosomal stability and suggest a potential tumor suppressor function in vivo.
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页码:1549 / 1557
页数:9
相关论文
共 65 条
[1]
CHOP (GADD153) AND ITS ONCOGENIC VARIANT, TLS-CHOP, HAVE OPPOSING EFFECTS ON THE INDUCTION OF G(1)/S ARREST
[J].
BARONE, MV
;
CROZAT, A
;
TABAEE, A
;
PHILIPSON, L
;
RON, D
.
GENES & DEVELOPMENT,
1994, 8 (04)
:453-464

BARONE, MV
论文数: 0 引用数: 0
h-index: 0
机构: NYU MED CTR,DEPT MED,NEW YORK,NY 10016

CROZAT, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU MED CTR,DEPT MED,NEW YORK,NY 10016

TABAEE, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU MED CTR,DEPT MED,NEW YORK,NY 10016

PHILIPSON, L
论文数: 0 引用数: 0
h-index: 0
机构: NYU MED CTR,DEPT MED,NEW YORK,NY 10016

RON, D
论文数: 0 引用数: 0
h-index: 0
机构: NYU MED CTR,DEPT MED,NEW YORK,NY 10016
[2]
Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts -: Dual actions of cAMP-dependent protein kinase on CCAAT/enhancer-binding protein δ
[J].
Billiard, J
;
Grewal, SS
;
Lukaesko, L
;
Stork, PJS
;
Rotwein, P
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (33)
:31238-31246

Billiard, J
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97201 USA

Grewal, SS
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97201 USA

Lukaesko, L
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97201 USA

Stork, PJS
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97201 USA

Rotwein, P
论文数: 0 引用数: 0
h-index: 0
机构: Oregon Hlth & Sci Univ, Div Mol Med, Dept Med, Portland, OR 97201 USA
[3]
Transcription factor C/EBP delta in fetal lung: Developmental regulation and effects of cyclic adenosine 3',5'-monophosphate and glucocorticoids
[J].
Breed, DR
;
Margraf, LR
;
Alcorn, JL
;
Mendelson, CR
.
ENDOCRINOLOGY,
1997, 138 (12)
:5527-5534

Breed, DR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235

Margraf, LR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235

Alcorn, JL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235

Mendelson, CR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235
[4]
C/EBPα and C/EBPδ activate the Clara cell secretory protein gene through interaction with two adjacent C/EBP-binding sites
[J].
Cassel, TN
;
Nordlund-Möller, L
;
Andersson, O
;
Gustafsson, JÅ
;
Nord, M
.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,
2000, 22 (04)
:469-480

Cassel, TN
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden

Nordlund-Möller, L
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden

Andersson, O
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden

Gustafsson, JÅ
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden

Nord, M
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Dept Med Nutr, S-14186 Huddinge, Sweden
[5]
Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription
[J].
Charles, A
;
Tang, XR
;
Crouch, E
;
Brody, JS
;
Xiao, ZXJ
.
JOURNAL OF CELLULAR BIOCHEMISTRY,
2001, 83 (03)
:414-425

Charles, A
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA

Tang, XR
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA

Crouch, E
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA

Brody, JS
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA

Xiao, ZXJ
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA
[6]
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
[J].
Chen, PL
;
Riley, DJ
;
ChenKiang, S
;
Lee, WH
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996, 93 (01)
:465-469

Chen, PL
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029 CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029

Riley, DJ
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029 CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029

ChenKiang, S
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029 CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029

Lee, WH
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029 CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029
[7]
Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
[J].
Chen, PL
;
Riley, DJ
;
Chen, YM
;
Lee, WH
.
GENES & DEVELOPMENT,
1996, 10 (21)
:2794-2804

Chen, PL
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245 UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245

Riley, DJ
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245 UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245

Chen, YM
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245 UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245

Lee, WH
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245 UNIV TEXAS,HLTH SCI CTR,CTR MOL MED,INST BIOTECHNOL,SAN ANTONIO,TX 78245
[8]
Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta - A critical role for protein kinase A-mediated phosphorylation of Ser(299)
[J].
Chinery, R
;
Brockman, JA
;
Dransfield, DT
;
Coffey, RJ
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1997, 272 (48)
:30356-30361

Chinery, R
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,MED CTR,DEPT CELL BIOL,NASHVILLE,TN 37232

Brockman, JA
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,MED CTR,DEPT CELL BIOL,NASHVILLE,TN 37232

Dransfield, DT
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,MED CTR,DEPT CELL BIOL,NASHVILLE,TN 37232

Coffey, RJ
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,MED CTR,DEPT CELL BIOL,NASHVILLE,TN 37232
[9]
Transforming growth factor-β inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
[J].
Choy, L
;
Derynck, R
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (11)
:9609-9619

Choy, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Growth & Dev, Program Cell Biol, San Francisco, CA 94143 USA

Derynck, R
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Growth & Dev, Program Cell Biol, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Growth & Dev, Program Cell Biol, San Francisco, CA 94143 USA
[10]
RULES AND GUIDELINES FOR NOMENCLATURE OF MOUSE GENES
[J].
DAVISSON, MT
.
GENE,
1994, 147 (02)
:157-160

DAVISSON, MT
论文数: 0 引用数: 0
h-index: 0
机构:
JACKSON LAB,INT COMM STAND GENET NOMENCLATURE MICE,BAR HARBOR,ME 04609 JACKSON LAB,INT COMM STAND GENET NOMENCLATURE MICE,BAR HARBOR,ME 04609