Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions?

被引：27

作者：

García-Nieto, R

Manzanares, I

Cuevas, C

Gago, F ^{[1
]}

机构：

[1] Univ Alcala de Henares, Dept Farmacol, E-28871 Alcala De Henares, Spain

[2] Pharma Mar, E-28760 Madrid, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 23期

关键词：

D O I：

10.1021/jm000322d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：4367 / 4369

页数：3

共 35 条

[1] FUNCTIONAL-ROLE FOR SP1 IN THE TRANSCRIPTIONAL AMPLIFICATION OF A CELL-CYCLE-REGULATED HISTONE H4 GENE [J].

BIRNBAUM, MJ ;

WRIGHT, KL ;

VANWIJNEN, AJ ;

RAMSEYEWING, AL ;

BOURKE, MT ;

LAST, TJ ;

AZIZ, F ;

FRENKEL, B ;

RAO, BR ;

ARONIN, N ;

STEIN, GS ;

STEIN, JL .

BIOCHEMISTRY, 1995, 34 (23) :7648-7658

[2] Growth/cell cycle regulation of Sp1 phosphorylation [J].

Black, AR ;

Jensen, D ;

Lin, SY ;

Azizkhan, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (03) :1207-1215

[3] Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins [J].

Bohm, S ;

Frishman, D ;

Mewes, HW .

NUCLEIC ACIDS RESEARCH, 1997, 25 (12) :2464-2469

[4]

Bonfanti M, 1999, ANTI-CANCER DRUG DES, V14, P179

[5] Physical basis of a protein-DNA recognition code [J].

Choo, Y ;

Klug, A .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (01) :117-125

[6] High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger DNA recognition [J].

Elrod-Erickson, M ;

Benson, TE ;

Pabo, CO .

STRUCTURE, 1998, 6 (04) :451-464

[7] Zif268 protein-DNA complex refined at 1.6 angstrom: A model system for understanding zinc finger-DNA interactions [J].

ElrodErickson, M ;

Rould, MA ;

Nekludova, L ;

Pabo, CO .

STRUCTURE, 1996, 4 (10) :1171-1180

[8] Bending of DNA upon binding of ecteinascidin 743 and phthalascidin 650 studied by unrestrained molecular dynamics simulations [J].

García-Nieto, R ;

Manzanares, I ;

Cuevas, C ;

Gago, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (30) :7172-7182

[9] GC BOX BINDING INDUCES PHOSPHORYLATION OF SP1 BY A DNA-DEPENDENT PROTEIN-KINASE [J].

JACKSON, SP ;

MACDONALD, JJ ;

LEESMILLER, S ;

TJIAN, R .

CELL, 1990, 63 (01) :155-165

[10] Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation [J].

Jin, S ;

Gorfajn, B ;

Faircloth, G ;

Scotto, KW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6775-6779

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