Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation

被引：68

作者：

Khalil, Ayman ^{[1
]}

Villard, Pierre-Henri ^{[1
]}

Dao, Maih Anh ^{[1
]}

Burcelin, Remy ^{[2
]}

Champion, Serge ^{[1
]}

Fouchier, Francis ^{[1
]}

Savouret, Jean-Francois ^{[3
]}

Barra, Yves ^{[1
]}

Seree, Eric ^{[1
]}

机构：

[1] Univ Mediterranee, INRA, Nutriments Lipid & Prevent Malad Metab UMR1260, 27 Blvd Jean Moulin, F-13385 Marseille, France

[2] Hop Rangueil, IFR31, Inst Mol Med, INSERM,U858, Toulouse, France

[3] Univ Paris 05, UFR Biomed, INSERM, UMR 747, F-75006 Paris, France

来源：

TOXICOLOGY LETTERS | 2010年 / 196卷 / 03期

关键词：

Polycyclic aromatic hydrocarbon; Benzo(a)pyrene; Inflammation; High-fat diet; Type; 2; diabetes; GLP-1; PERSISTENT ORGANIC POLLUTANTS; UNCOUPLING PROTEIN-2; SERUM CONCENTRATIONS; METABOLIC SYNDROME; MESSENGER-RNA; UP-REGULATION; OBESITY; RECEPTOR; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.toxlet.2010.04.010

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We demonstrate that intestinal inflammation caused by high-fat diet is increased by the environmental contaminant benzo[a]pyrene. Our in vivo results indicate that a high-fat diet (HFD) induces a pre-diabetic state in mice compared with animals fed normal chow. HFD increased IL-1 beta mRNA concentration in the jejunum, colon, and liver, and TNF alpha was increased in the colon and strongly increased in the liver. HFD also increased the expression of other genes related to type 2 diabetes, such as the uncoupling protein UCP2, throughout the bowel and liver, but not in the colon. The treatment of HFD with BaP enhanced the expression of IL-1 beta in the liver and TNF alpha throughout the bowel and in the liver. Adding BaP to the diet also caused a significant decrease in the expression of the incretin glucagon-like peptide 1, which plays an important role in insulin secretion. Our results suggest that intestinal inflammation may be involved in the onset of type 2 diabetes and that chronic exposure to environmental polycyclic aromatic hydrocarbons can increase the risk of type 2 diabetes by inducing pro-inflammatory cytokine production. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：161 / 167

页数：7

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