Neurotrophins, synaptic plasticity and dementia

被引：148

作者：

Arancio, Ottavio

Chao, Moses V.

机构：

[1] Columbia Univ, Coll Phys & Surg, Taub Inst, Dept Pathol, New York, NY 10032 USA

[2] NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol Physiol & Neurosci, New York, NY 10016 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.conb.2007.03.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The growing realization that neurotrophins, such as brain-derived neurotrophic factor (BDNF), are crucial in modulating synaptic plasticity has broadened the spectrum of their trophic actions. At the same time, it has become clear that A beta peptides derived from amyloid precursor protein (APP) have dramatic effects on synaptic transmission before the onset of the neurodegenerative disease. Because neurotrophins and A beta are responsible for affecting both synaptic and cognitive function, it is likely that their mechanisms of action will be related and might even intersect. This review highlights several recent findings that suggest trophic factors and APP use similar pathways to control neuronal activity.

引用

页码：325 / 330

页数：6

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