Alterations of calcium uptake in renovascular hypertensive rat aorta: Functional assessment with thapsigargin

被引：8

作者：

Ceron, PIB ^{[1
]}

Bendhack, LM ^{[1
]}

机构：

[1] Univ Sao Paulo, Coll Pharmaceut Sci, Pharmacol Lab, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

GENERAL PHARMACOLOGY | 1998年 / 31卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

renal hypertension; thapsigargin; 1; kidney; clip; sarcoplasmic reticulum;

D O I：

10.1016/S0306-3623(97)00445-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The aim of this study was to test the hypothesis that impaired calcium (Ca2+) recycling by sarcoplasmic reticulum (SR) Ca2+-ATPase takes place in aortae from 1 kidney-1 clip (1K-1C) hypertensive rats. 2. The contractile response elicited when Ca2+ is released from the SR with phenylephrine and caffeine in Ca2+-free Krebs solution was greater in 1K-1C than in 1K rat aorta. In the arteries submitted to intracellular Ca2+ store depletion and reloading, this response was not different between 1K-1C and 1K rat aortae. Thapsigargin decreased the phasic contractile responses to phenylephrine in 1K and 1K 1C rat aortae and increased the tone that developed during the refilling period in 1K-1C rat aortae. 3. Our data support the hypothesis that the 1K 1C rat aorta has defective intracellular Ca2+ regulation that may be implicated in an inadequate SR buffering ability. (C) 1998 Elsevier Science Inc.

引用

页码：265 / 270

页数：6

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