Pathophysiological, role of cytokines in congestive heart failure

被引：102

作者：

Blum, A ^{[1
]}

Miller, H

机构：

[1] Poria Hosp, Dept Internal Med, IL-15208 Lower Galilee, Israel

[2] Tel Aviv Sourasky Med Ctr, Catheterizat Lab, Dept Cardiol, IL-64239 Tel Aviv, Israel

来源：

ANNUAL REVIEW OF MEDICINE | 2001年 / 52卷

关键词：

interleukin-1; beta; interleukin-2; interleukin-6; tumor necrosis factor alpha; atrial natriuretic factor; dilated cardiomyopathy; major histocompatibility complex; monoclonal antibodies;

D O I：

10.1146/annurev.med.52.1.15

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Heart failure is a complex neurohumoral and inflammatory syndrome. Recent studies have shown that proinflammatory cytokines (interleukin-1, interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor) are involved in cardiac depression and in the complex syndrome of heart failure. Understanding the involvement of these cytokines may enable us to reverse cardiac depression and heart failure by the use of monoclonal antibodies directed against specific cytokines to block the downhill progression of heart failure.

引用

页码：15 / 27

页数：13

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