The bicyclam AMD3 100 story

被引：392

作者：

De Clercq, E ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrd1134

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The discovery and development of the bicyclam AMD3100 - a chemokine receptor antagonist - has highlighted the therapeutic potential of such compounds in HIV infection, inflammatory diseases, cancer and stem-cell mobilization. Here, I describe the development process of AMD3100, which began about 15 years ago with the isolation of an impurity, and the basis for the clinical application of AMD3100 and its congeners.

引用

页码：581 / 587

页数：7

共 50 条

[1] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease [J].

Berger, EA ;

Murphy, PM ;

Farber, JM .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :657-700

[2]

Broxmeyer HE, 2002, BLOOD, V100, p609A

[3]

BROXMEYER HE, 2001, AM SOC HEM ANN M ORL, V98, pA811

[4]

DALE DC, 2002, INT SOC HEM M QUEB C

[5] Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry [J].

Datema, R ;

Rabin, L ;

Hincenbergs, M ;

Moreno, MB ;

Warren, S ;

Linquist, V ;

Rosenwirth, B ;

Seifert, J ;

McCune, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (03) :750-754

[6] Hamao Umezawa Memorial Award lecture 'an odyssey in the viral chemotherapy field' [J].

De Clercq, E .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 18 (04) :309-328

[7] HIGHLY POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS BY THE BICYCLAM DERIVATIVE JM3100 [J].

DE CLERCQ, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BALZARINI, J ;

WITVROUW, M ;

DEVREESE, K ;

DEBYSER, Z ;

ROSENWIRTH, B ;

PEICHL, P ;

DATEMA, R ;

THORNTON, D ;

SKERLJ, R ;

GAUL, F ;

PADMANABHAN, S ;

BRIDGER, G ;

HENSON, G ;

ABRAMS, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (04) :668-674

[8]

De Clercq E, 1997, Met Based Drugs, V4, P173, DOI 10.1155/MBD.1997.173

[9]

De Clercq E, 2000, MOL PHARMACOL, V57, P833

[10] POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-1 AND HIV-2 REPLICATION BY A CLASS OF BICYCLAMS INTERACTING WITH A VIRAL UNCOATING EVENT [J].

DECLERCO, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BABA, M ;

SCHOLS, D ;

NAKASHIMA, H ;

BALZARINI, J ;

DEBYSER, Z ;

MURRER, BA ;

SCHWARTZ, D ;

THORNTON, D ;

BRIDGER, G ;

FRICKER, S ;

HENSON, G ;

ABRAMS, M ;

PICKER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5286-5290

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