Towards the total synthesis of phorboxazoles A and B:: Stereocontrolled synthesis of a C20-C32 subunit

被引：76

作者：

Paterson, I ^{[1
]}

Arnott, EA ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)01539-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-20-C-32 phorboxazole subunit 4, containing 5 stereocentres, was prepared in 8 steps (34%) from ethyl ketone (S)-7. Key steps included a boron-mediated anti aldol reaction and an intramolecular hetero-Michael reaction. Installation of the C-19-C-20 (E)-alkene using a Wittig reaction produced a C-15-C-32 fragment, including both oxazoles present in the natural product. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：7185 / 7188

页数：4

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