Molecular interactions of acetylcholinesterase with senile plaques

被引：57

作者：

Inestrosa, NC ^{[1
]}

Alarcon, R ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Santiago, Chile

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 5-6期

关键词：

AChE; amyloid plaques; AChE-A beta-amyloid fibril complexes; Alzheimer's disease;

D O I：

10.1016/S0928-4257(99)80002-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects. ((C) Elsevier, Paris).

引用

页码：341 / 344

页数：4

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