Gene-environment interactions in chronic inflammatory disease

被引：116

作者：

Renz, Harald ^{[1
]}

von Mutius, Erika ^{[2
]}

Brandtzaeg, Per ^{[3
,4
]}

Cookson, William O. ^{[5
]}

Autenrieth, Ingo B. ^{[6
]}

Haller, Dirk ^{[7
,8
]}

机构：

[1] Univ Marburg, Inst Lab Med & Pathobiochem, Marburg, Germany

[2] Univ Munich, Dr von Hauner Childrens Hosp, Munich, Germany

[3] Univ Oslo, Ctr Immune Regulat, Lab Immunohistochem & Immunopathol, Oslo, Norway

[4] Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Pathol, N-0027 Oslo, Norway

[5] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[6] Univ Tubingen Hosp, Inst Med Microbiol & Hyg, Tubingen, Germany

[7] Tech Univ Munich, Res Ctr Nutr & Food Sci, Sect Biofunct, Munich, Germany

[8] Tech Univ Munich, Ctr Diet & Dis, Munich, Germany

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; LINKS INNATE IMMUNITY; EPIGENETIC CONTROL; CROHNS-DISEASE; PATHOGENESIS; MICROBIOTA; ASTHMA; HOMEOSTASIS; EXPRESSION; PROBIOTICS;

D O I：

10.1038/ni0411-273

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammatory diseases represent a major challenge for both clinical research and patient care, and evidence indicates that these disorders develop as a result of complex gene-environment interactions. Better understanding of their cause-and-effect relationship is the basis for emerging proposals for therapy and prevention.

引用

页码：273 / 277

页数：5

共 51 条

[1]

[Anonymous], ADV EXPT MED BIOL

[2] New therapies for asthma: is there any progress? [J].