Carbon monoxide cardiotoxicity

被引:93
作者
Gandini, C
Castoldi, AF
Candura, SM
Locatelli, C
Butera, R
Priori, S
Manzo, L
机构
[1] Inst Pavia, Salvatore Maugeri Fdn, Toxicol Unit, IRCCS, I-27100 Pavia, Italy
[2] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy
来源
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2001年 / 39卷 / 01期
关键词
carbon monoxide; cardiotoxicity; diagnosis;
D O I
10.1081/CLT-100102878
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Cardiac dysfunction including arrhythmias and myocardial ischemia have often been reported in carbon monoxide poisoning; scattered punctiform hemorrhages throughout the heart have been documented in autopsy samples. An appropriate diagnostic approach is crucial to assess carbon monoxide cardiac damage. This evaluation may be confounded by several factors, including the absence of overt symptoms and of specific ischemic changes in the electrocardiogram. In experimental studies, laboratory animals can develop cardiac changes similar to those seen in humans and therefore proved to be useful models to study the effects and the mechanisms of cardiac damage due to carbon monoxide. These investigations, as well as others performed in vitro, provide support for a direct action of carbon monoxide on the heart, in addition to systemic hypoxia produced by carboxyhemoglobin formation. This review focuses on the diagnostic aspects of carbon monoxide cardiotoxicity. Experimental results obtained in animals and in vitro models are also discussed.
引用
收藏
页码:35 / 44
页数:10
相关论文
共 93 条
[1]   DIAGNOSIS OF PERIOPERATIVE MYOCARDIAL-INFARCTION WITH MEASUREMENT OF CARDIAC TROPONIN-I [J].
ADAMS, JE ;
SICARD, GA ;
ALLEN, BT ;
BRIDWELL, KH ;
LENKE, LG ;
DAVILAROMAN, VG ;
BODOR, GS ;
LADENSON, JH ;
JAFFE, AS .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (10) :670-674
[2]   SHORT-TERM EFFECTS OF CARBON-MONOXIDE EXPOSURE ON THE EXERCISE PERFORMANCE OF SUBJECTS WITH CORONARY-ARTERY DISEASE [J].
ALLRED, EN ;
BLEECKER, ER ;
CHAITMAN, BR ;
DAHMS, TE ;
GOTTLIEB, SO ;
HACKNEY, JD ;
PAGANO, M ;
SELVESTER, RH ;
WALDEN, SM ;
WARREN, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (21) :1426-1432
[3]  
*AM C GOV IND HYG, 1997, 1997 1998 THRESH LIM
[4]   MYOCARDIAL TOXICITY FROM CARBON MONOXIDE POISONING [J].
ANDERSON, RF ;
ALLENSWORTH, DC ;
DEGROOT, WJ .
ANNALS OF INTERNAL MEDICINE, 1967, 67 (06) :1172-+
[5]   UNSTABLE ANGINA AND EXPOSURE TO CARBON-MONOXIDE [J].
BALZAN, MV ;
CACCIOTTOLO, JM ;
MIFSUD, S .
POSTGRADUATE MEDICAL JOURNAL, 1994, 70 (828) :699-702
[6]   CARBON-MONOXIDE POISONING, A DIAGNOSIS FREQUENTLY OVERLOOKED [J].
BARRET, L ;
DANEL, V ;
FAURE, J .
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1985, 23 (4-6) :309-313
[7]  
Bernard C., 1857, LECONS EFFETS SUBSTA
[8]   BIOCHEMICAL MARKERS OF MYOCARDIAL DAMAGE [J].
BHAYANA, V ;
HENDERSON, AR .
CLINICAL BIOCHEMISTRY, 1995, 28 (01) :1-29
[9]   CARBON-MONOXIDE AND CULTURED RAT-HEART CELLS .1. INHIBITION OF CELL-GROWTH AND MAINTENANCE OF BEATING RATE [J].
BRENNER, GM ;
WENZEL, DG .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1972, 23 (02) :251-&
[10]   Association between ambient carbon monoxide levels and hospitalizations for congestive heart failure in the elderly in 10 Canadian cities [J].
Burnett, RT ;
Dales, RE ;
Brook, JR ;
Raizenne, ME ;
Krewski, D .
EPIDEMIOLOGY, 1997, 8 (02) :162-167