Entamoeba histolytica:: Signaling through G proteins

被引：8

作者：

Paveto, C

Torres, HN

Flawia, MM

García-Espitia, M

Ortega, A

Orozco, E

机构：

[1] Inst Invest Ingn Genet & Biol Mol, RA-1428 Buenos Aires, DF, Argentina

[2] Fac Ciencias Exactas & Nat, RA-1428 Buenos Aires, DF, Argentina

[3] Inst Politecn Nacl, CINVESTAV, Dept Mol Biol & Genet, Mexico City 07000, DF, Mexico

[4] IPN, CICATA, Mexico City 07738, DF, Mexico

来源：

EXPERIMENTAL PARASITOLOGY | 1999年 / 91卷 / 02期

关键词：

Entamoeba histolytica; guanine nucleotide binding proteins; signal transduction;

D O I：

10.1006/expr.1998.4361

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The intracellular signaling pathways of Entamoeba histolytica are largely unknown. Although the expression of guanine nucleotide binding proteins (G proteins) is expected from functional studies, their biochemical characterization remains elusive in this protozoan. Using a combination of biochemical and immunological studies, we provide strong evidence for the presence of a G(s) protein in amoeba. Our results strengthen our understanding of the signal transduction mechanisms in E. histolytica as potential sites of a new therapeutic strategy. (C) 1999 Academic Press.

引用

页码：170 / 175

页数：6

共 19 条

[1] A SINGLE COLUMN METHOD FOR THE ASSAY OF ADENYLATE-CYCLASE [J].