Immunity to malaria: more questions than answers

被引：632

作者：

Langhorne, Jean ^{[1
]}

Ndungu, Francis M. ^{[1
]}

Sponaas, Anne-Marit ^{[1
]}

Marsh, Kevin ^{[2
]}

机构：

[1] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

[2] Kenya Govt Med Res Ctr, Wellcome Trust Collaborat Project, Kilifi, Kenya

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 07期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/ni.f.205

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria is one of the main health problems facing developing countries today. At present, preventative and treatment strategies are continuously hampered by the issues of the ever-emerging parasite resistance to newly introduced drugs, considerable costs and logistical problems. The main hope for changing this situation would be the development of effective malaria vaccines. An important part of this process is understanding the mechanisms of naturally acquired immunity to malaria. This review will highlight key aspects of immunity to malaria, about which surprisingly little is known and which will prove critical in the search for effective malaria vaccines.

引用

页码：725 / 732

页数：8

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