Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule

被引：39

作者：

Nakano, Hirofumi ^{[2
]}

Soda, Hiroshi ^{[1
,2
]}

Takasu, Mineyo ^{[3
]}

Tomonaga, Nanae ^{[2
]}

Yamaguchi, Hiroyuki ^{[2
]}

Nakatomi, Katsumi ^{[2
]}

Fujino, Satoru ^{[4
]}

Hayashi, Tomayoshi ^{[5
]}

Nakamura, Yoichi ^{[2
]}

Tsukamoto, Kazuhiro ^{[3
]}

Kohno, Shigeru ^{[2
]}

机构：

[1] Sasebo City Gen Hosp, Div Resp Med, Sasebo 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmacotherapeut, Nagasaki 8528521, Japan

[4] St Francisco Hosp, Nagasaki 8528125, Japan

[5] Nagasaki Univ Hosp, Dept Pathol, Nagasaki 8528501, Japan

来源：

LUNG CANCER | 2008年 / 60卷 / 01期

关键词：

lung cancer; atypical adenomatous hyperplasia; bronchioloalveotar carcinoma; mixed adenocarcinoma; epidermal growth factor receptor mutations; gefitinib;

D O I：

10.1016/j.lungcan.2007.08.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC areas. EGFR mutations may accumulate during tumor progression and lead to heterogeneity of EGFR mutations within the tumor. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 140

页数：5

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