Molecular Basis of Antibody-Mediated Neutralization and Protection Against Flavivirus

被引：45

作者：

Dai, Lianpan ^{[1
]}

Wang, Qihui ^{[2
,3
]}

Qi, Jianxun ^{[4
]}

Shi, Yi ^{[1
,3
,4
,5
,6
]}

Yan, Jinghua ^{[2
,3
,4
,6
]}

Gao, George F. ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Chinese Acad Sci, Beijing Inst Life Sci, RNIH, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing, Peoples R China

[3] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China

[4] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[5] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China

[6] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China

[7] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

来源：

IUBMB LIFE | 2016年 / 68卷 / 10期

基金：

中国国家自然科学基金;

关键词：

flavivirus; antibodies; structural basis; neutralization; protection; WEST-NILE-VIRUS; BORNE ENCEPHALITIS-VIRUS; FC-GAMMA-RECEPTOR; CROSS-REACTIVE ANTIBODIES; CD4(+) T-CELLS; DENGUE VIRUS; DOMAIN-III; STRUCTURAL BASIS; ZIKA VIRUS; ENVELOPE GLYCOPROTEIN;

D O I：

10.1002/iub.1556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Antibody-mediated humoral immunity plays a pivotal role in flavivirus control. Neutralizing antibodies targeting viral envelope (E) protein, provide protection against flaviviruses in vivo but can also promote virus infection by antibody-dependent enhancement when antibodies are weakly neutralizing or in subneutralizing concentrations. The molecular basis for antibody-mediated virus neutralization can be revealed by structural studies of monoclonal antibodies complexed with the E protein or virion. In addition, the flavivirus non-structural protein NS1 can also induce host antibody production, and some of these antibodies can provide protection against virus challenge. In this review, we summarize the known structures of flavivirus neutralizing or protective antibodies bound to their epitopes and describe the underlying molecular mechanisms. (C) 2016 IUBMB Life, 68(10):783-791, 2016

引用

页码：783 / 791

页数：9

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