Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam study

被引：46

作者：

Slooter, AJC

Houwing-Duistermaat, JJ

van Harskamp, F

Cruts, M

Van Broeckhoven, C

Breteler, MMB

Hofman, A

Stijnen, T

van Duijn, CM

机构：

[1] Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus Univ, Univ Rotterdam Hosp, Sch Med, Dept Neurol, Rotterdam, Netherlands

[3] Univ Antwerp VIB, Born Bunge Fdn, Dept Biochem, Neurogenet Lab, B-2020 Antwerp, Belgium

来源：

JOURNAL OF NEUROLOGY | 1999年 / 246卷 / 04期

关键词：

Alzheimer's disease; apolipoprotein E; progression; survival;

D O I：

10.1007/s004150050351

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patients were included at a similar stage, i.e., before the onset of symptoms, and followed for up to 5 years. We found that the APOE*4 allele is not a strong determinant of survival in AD. As change in cognitive function and severity of dementia are similar for AD patients with and without APOE*4, our study suggests that progression of AD is not related to the APOE*4 allele.

引用

收藏

页码：304 / 308

页数：5

相关论文

共 26 条

[1] APOLIPOPROTEIN EPSILON-4 ALLELE AND DISEASE PROGRESSION IN PATIENTS WITH LATE-ONSET ALZHEIMERS-DISEASE [J].

BASUN, H ;

GRUT, M ;

WINBLAD, B ;

LANNFELT, L .

NEUROSCIENCE LETTERS, 1995, 183 (1-2) :32-34

[2] Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease [J].

Bronzova, J ;

vanDuijn, CM ;

Havekes, LM ;

deKnijff, P ;

Van Broeckhoven, C ;

Hofman, A .

JOURNAL OF NEUROLOGY, 1996, 243 (06) :465-468

[3] APOLIPOPROTEIN-E, SURVIVAL IN ALZHEIMERS-DISEASE PATIENTS, AND THE COMPETING RISKS OF DEATH AND ALZHEIMERS-DISEASE [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

RIMMLER, JB ;

LOCKE, PA ;

CONNEALLY, PM ;

SCHMADER, KE ;

TANZI, RE ;

GUSELLA, JF ;

SMALL, GW ;

ROSES, AD ;

PERICAKVANCE, MA ;

HAINES, JL .

NEUROLOGY, 1995, 45 (07) :1323-1328

[4]

DalForno G, 1996, ARCH NEUROL-CHICAGO, V53, P345

[5]

Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.1997.03550160069041

[6] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[7] GENE DOSE OF THE EPSILON-4 ALLELE OF APOLIPOPROTEIN-E AND DISEASE PROGRESSION IN SPORADIC LATE-ONSET ALZHEIMERS-DISEASE [J].

FRISONI, GB ;

GOVONI, S ;

GEROLDI, C ;

BIANCHETTI, A ;

CALABRESI, L ;

FRANCESCHINI, G ;

TRABUCCHI, M .

ANNALS OF NEUROLOGY, 1995, 37 (05) :596-604

[8] CLINICAL-NEUROPATHOLOGICAL CORRELATIONS IN ALZHEIMERS-DISEASE AND RELATED DEMENTIAS [J].

GALASKO, D ;

HANSEN, LA ;

KATZMAN, R ;

WIEDERHOLT, W ;

MASLIAH, E ;

TERRY, R ;

HILL, R ;

LESSIN, P ;

THAL, LJ .

ARCHIVES OF NEUROLOGY, 1994, 51 (09) :888-895

[9] Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease [J].

GomezIsla, T ;

West, HL ;

Rebeck, GW ;

Harr, SD ;

Growdon, JH ;

Locascio, JJ ;

Perls, TT ;

Lipsitz, LA ;

Hyman, BT .

ANNALS OF NEUROLOGY, 1996, 39 (01) :62-70

[10] Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease [J].

Growdon, JH ;

Locascio, JJ ;

Corkin, S ;

GomezIsla, T ;

Hyman, BT .

NEUROLOGY, 1996, 47 (02) :444-448