The mechanism of proton transport mediated by mitochondrial uncoupling proteins

被引：121

作者：

Garlid, KD

Jaburek, M

Jezek, P

机构：

[1] Oregon Grad Inst Sci & Technol, Dept Biochem & Mol Biol, Portland, OR 97291 USA

[2] Acad Sci Czech Republic, Inst Physiol, Dept Membrane Transport Biophys, CZ-142220 Prague, Czech Republic

来源：

FEBS LETTERS | 1998年 / 438卷 / 1-2期

关键词：

uncoupling protein; fatty acid; H+ transport; chloride transport; mutagenesis;

D O I：

10.1016/S0014-5793(98)01246-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effort to understand the mechanism of uncoupling by UCP has devolved into two models - the fatty acid protonophore model and the proton buffering model, Evidence for each hypothesis is summarized and evaluated. We also evaluate the obligatory requirement for fatty acids in UCP1-mediated uncoupling and the question of fatty acid affinity for UCP1, The structural bases of UCP transport function and nucleotide inhibition are discussed in light of recent mutagenesis studies and in relationship to the sequences of newly discovered UCPs, (C) 1998 Federation of European Biochemical Societies.

引用

页码：10 / 14

页数：5

共 33 条

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