Relationship between short- and long-term memory and short- and long-term extinction

被引：37

作者：

Cammarota, M

Bevilaqua, LRM

Rossato, JI

Ramirez, M

Medina, JH

Izquierdo, I ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Inst Pesquisas Biomed, Ctr Memoria, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, Porto Alegre, RS, Brazil

[3] Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias Prof Dr Eduardo, Lab Neuroreceptores, RA-1053 Buenos Aires, DF, Argentina

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2005年 / 84卷 / 01期

关键词：

learning; memory; extinction; short-term memory; long-term memory; hippocampus; AP5; NMDA; anisomycin; protein synthesis;

D O I：

10.1016/j.nlm.2005.03.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CAI region of the dorsal hippocampus at the time of the first CS-no US presentation. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：25 / 32

页数：8

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