Immunotoxic effects of organotin compounds in Tapes philippinarum

被引：41

作者：

Cima, F

Marin, MG

Matozzo, V

Da Ros, L

Ballarin, L

机构：

[1] Univ Padua, Dept Biol, I-35121 Padua, Italy

[2] CNR, Inst Marine Biol, I-30122 Venice, Italy

来源：

CHEMOSPHERE | 1998年 / 37卷 / 14-15期

关键词：

D O I：

10.1016/S0045-6535(98)00345-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 [工学]; 0830 [环境科学与工程];

摘要：

One of the most harmful groups of coastal pollutants is the organotin compounds (OTCs) which have severe effects on both aquatic organisms and mammals including humans. The immunotoxic effects of OTCs were studied in the cultivated clam Tapes philippinarum by determining the immunosuppressant role on in vitro yeast phagocytosis at low doses (0.01, 0.05, 0.1 mu M). The phagocytic index was significantly reduced in an irreversible non-lethal manner depending on concentration and lipophilic affinity. The order of inhibition was TBT greater than or equal to DBT greater than or equal to MBT for butyltins and TPTC>TPTA greater than or equal to TPTH for triphenyltins. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3035 / 3045

页数：11

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