Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity

被引：65

作者：

Marcou, Y

D'Andrea, A

Jeggo, PA

Plowman, PN ^{[1
]}

机构：

[1] St Bartholomews Hosp, Dept Clin Oncol, London EC1A 7BE, England

[2] Harvard Univ, Childrens Hosp, Sch Med, Dana Farber Canc Inst,Dept Pediat Oncol, Boston, MA 02115 USA

[3] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1, E Sussex, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2001年 / 60卷 / 01期

关键词：

Fanconi anaemia; severe acute reaction; cellular radiosensitivity;

D O I：

10.1016/S0167-8140(01)00370-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild cellular radiosensitivity has also been reported. Materials and methods: A 32-year-old patient with Fanconi anaemia and tonsillar carcinoma, treated by radiotherapy, was found to exhibit profound clinical radiosensitivity. Confluent, ulcerating oropharyngeal mucositis developed after a conventionally fractionated dose of 34 Gy and healing was incomplete by 2 months after cessation of therapy. Results: Cellular radiosensitivity assays and RPLD studies from this patient did not suggest any major detectable radiosensitivity. Conclusion: There is a discrepancy between the observed clinical radiosensitivity and the usual 'predictive' radiosensitivity assays in this patient with Fanconi anaemia. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：75 / 79

页数：5

共 23 条

[1] FANCONI-ANEMIA AND ITS VARIABILITY [J].