Telomeres, stem cells, senescence, and cancer

被引：351

作者：

Sharpless, NE ^{[1
]}

DePinho, RA

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Dept Med & Genet, Chapel Hill, NC 27599 USA

[2] Harvard Univ, Sch Med, Dept Adult Oncol, Dana Farber Canc Inst,Dept Med & Genet, Boston, MA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 02期

关键词：

D O I：

10.1172/JCI200420761

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.

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页码：160 / 168

页数：9

相关论文

共 127 条

[1] Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts [J].

Alcorta, DA ;

Xiong, Y ;

Phelps, D ;

Hannon, G ;

Beach, D ;

Barrett, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13742-13747

[2] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS [J].

ALLSOPP, RC ;

VAZIRI, H ;

PATTERSON, C ;

GOLDSTEIN, S ;

YOUNGLAI, EV ;

FUTCHER, AB ;

GREIDER, CW ;

HARLEY, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10114-10118

[3] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[4] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[5] A critical role for telomeres in suppressing and facilitating carcinogenesis [J].

Artandi, SE ;

DePinho, RA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :39-46

[6] The cell cycle inhibitor p16INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels [J].

Ausserlechner, MJ ;

Obexer, P ;

Wiegers, GJ ;

Hartmann, BL ;

Geley, S ;

Kofler, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (14) :10984-10989

[7] Atm-deficient mice: A paradigm of ataxia telangiectasia [J].

Barlow, C ;

Hirotsune, S ;

Paylor, R ;

Liyanage, M ;

Eckhaus, M ;

Collins, F ;

Shiloh, Y ;

Crawley, JN ;

Ried, T ;

Tagle, D ;

WynshawBoris, A .

CELL, 1996, 86 (01) :159-171

[8] Reversal of human cellular senescence:: roles of the p53 and p16 pathways [J].

Beauséjour, CM ;

Krtolica, A ;

Galimi, F ;

Narita, M ;

Lowe, SW ;

Yaswen, P ;

Campisi, J .

EMBO JOURNAL, 2003, 22 (16) :4212-4222

[9] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

[10] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

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