Is Gilbert Syndrome a new risk factor for breast cancer?

被引：6

作者：

Astolfi, Rafael Haddad ^{[1
]}

Gomes Bugano, Diogo Diniz ^{[2
]}

Rodrigues Ferreira Francisco, Alice Aparecida ^{[3
]}

Tavares de Souza, Marcelo Moreira ^{[4
]}

Ono-Nita, Suzane Kioko ^{[5
]}

Baracat, Edmund Chada ^{[6
]}

机构：

[1] Univ Sao Paulo, Sch Med, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Hosp Clin, Dept Internal Med, BR-05508 Sao Paulo, Brazil

[3] Inst Brasileiro Controle Canc, Brasilia, DF, Brazil

[4] Univ Sao Paulo, Dept Hepatol, BR-05508 Sao Paulo, Brazil

[5] Univ Sao Paulo, Hosp Clin, Dept Gastroenterol, BR-05508 Sao Paulo, Brazil

[6] Univ Sao Paulo, Dept Gynecol, Hosp Clin, BR-05508 Sao Paulo, Brazil

来源：

MEDICAL HYPOTHESES | 2011年 / 77卷 / 02期

关键词：

UDP-GLUCURONOSYLTRANSFERASE; GENETIC POLYMORPHISMS; POSTMENOPAUSAL WOMEN; ENDOGENOUS ESTROGENS; BILIRUBIN METABOLISM; RECEPTOR STATUS; UGT1A1; PHENOTYPES;

D O I：

10.1016/j.mehy.2011.03.047

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Patients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：162 / 164

页数：3

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