Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for falciparum malaria

被引：49

作者：

Khanh, NX

de Vries, PJ

Ha, LD

van Boxtel, CJ

Koopmans, R

Kager, PA

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Infect Dis Trop Med & AIDS, NL-1100 DE Amsterdam, Netherlands

[2] Bach Mai Hosp, Inst Clin Res Trop Med, Hanoi, Vietnam

[3] Univ Amsterdam, Acad Med Ctr, Dept Clin Pharmacol & Pharmacotherapy, NL-1105 AZ Amsterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.690

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dibydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded. with a fast recovery.

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页码：690 / 692

页数：3

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