Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration

被引：13

作者：

Buemi, M ^{[1
]}

Allegra, A ^{[1
]}

Corica, F ^{[1
]}

Aloisi, C ^{[1
]}

Ruello, A ^{[1
]}

Giacobbe, MS ^{[1
]}

Di Pasquale, G ^{[1
]}

Senatore, M ^{[1
]}

Frisina, N ^{[1
]}

机构：

[1] Univ Messina, Dept Internal Med, Chair Nephrol, Messina, Italy

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1999年 / 12卷 / 01期

关键词：

lisinopril; bcl-2; nifedipine; hypertension; cold pressor test;

D O I：

10.1016/S0895-7061(98)00217-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In 30 patients with essential hypertension and 30 healthy control subjects, we evaluated blood concentrations of B cell leukemia-2 (bcl-2), a protooncogene that can reduce apoptosis. Bcl-2 concentrations were higher in hypertensive than in normotensive subjects. The increase in pressure due to a cold presser test caused a further increase in blood bcl-2 concentrations, in both hypertensive and normotensive subjects. Treatment of hypertensive patients with hypotensive drugs caused a reduction in bcl-2 concentrations, which was more marked after administration of lisinopril than of nifedipine, The results suggest that concentrations of bcl-2 are increased in patients with hypertension, which could be an important factor in cell proliferation underlying posthypertensive vascular remodeling. Moreover, lisinopril and nifedipine appear to be capable of reducing bcl-2 concentrations, with potentially beneficial effects on vascular modifications in patients with hypertension. (C) 1999 American Journal of Hypertension, Ltd.

引用

页码：73 / 75

页数：3

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