Gram negative sinusitis: A bacteriologic and histologic study in rabbits

被引:65
作者
Bolger, WE
Leonard, D
Dick, EJ
Stierna, P
机构
[1] Departments of Surgery (Otolaryngology), Uniformed Services University of the Health Sciences, Bethesda, MD
[2] Department of Otolaryngology, National Naval Medical Center-Bethesda, Bethesda, MD
[3] Pathobiology Division, Naval Medical Research Institute, Bethesda, MD
[4] Department of Otolaryngology, Huddinge Hospital, Karolinska Institute, Huddinee
[5] Uniformed Services, Bethesda
[6] University of the Health Sciences, Bethesda, MD 20814
来源
AMERICAN JOURNAL OF RHINOLOGY | 1997年 / 11卷 / 01期
关键词
D O I
10.2500/105065897781446766
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Recent investigations of chronic sinusitis that is ''recalcitrant'' to traditional medical and surgical therapy indicate that gram negative bacteria are frequently involved, most commonly Pseudomonas aeruginosa Analysis of infection-induced histopathologic changes in the underlying sinus mucosa may provide important insight into the recalcitrant nature of these infections. Therefore, the aim of this investigation is to experimentally induce sinus infection in the rabbit with Pseudomonas aeruginosa, a bacterium commonly associated with ''recalcitrant sinusitis, '' and evaluate the histopathologic findings. A unilateral maxillary sinusitis was induced in 33 New Zealand white rabbits. Histologic analysis at 4, 14, 21, and 28 days revealed a moderate inflammation that persisted throughout the study period. Initial changes included edema, loss of submucosal glands, and ulceration. Fibroplasia and bone remodeling were evident throughout the study. Epithelial plaque formation occurred early in the infection, whereas goblet cell formation was a later change. Experimental sinusitis induced by Pseudomonas aeruginosa causes an intense transmucosal injury. The histopathologic injury and response to Pseudomonas aeruginosa appears to be more intense than that noted on previous investigations of experimental sinusitis using other bacteria. The significant histopathologic changes noted could explain the recalcitrant nature of gram negative sinusitis observed clinically in patients.
引用
收藏
页码:15 / 25
页数:11
相关论文
共 16 条
[1]  
AUSTRIAN R, 1980, MICROBIOLOGY, P596
[2]   GRAM-NEGATIVE SINUSITIS - AN EMERGING CLINICAL ENTITY [J].
BOLGER, WE .
AMERICAN JOURNAL OF RHINOLOGY, 1994, 8 (06) :279-284
[3]   THE IMMUNOEVASIVE ACTIVITIES OF PSEUDOMONAS-AERUGINOSA - RELEVANCE FOR CYSTIC-FIBROSIS [J].
BURET, A ;
CRIPPS, AW .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (03) :793-805
[4]   ORBITOCEREBRAL COMPLICATIONS OF PSEUDOMONAS SINUSITIS [J].
CHEUNG, SW ;
LEE, KC ;
CHA, I .
LARYNGOSCOPE, 1992, 102 (12) :1385-1389
[5]   GRANULOCYTE PROTEASES IN HUMAN MAXILLARY SINUS SECRETIONS [J].
ENGQUIST, S ;
LUNDBERG, C ;
VENGE, P .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1983, 15 (01) :119-123
[6]  
FAIRBANKS DFN, 1991, AM ACAD OTOLARYNGOLO, P2
[7]   MUCOSAL PATHOLOGY OF THE NOSE AND SINUSES - A STUDY IN EXPERIMENTAL MAXILLARY SINUSITIS IN RABBITS INDUCED BY STREPTOCOCCUS-PNEUMONIAE, BACTEROIDES-FRAGILIS, AND STAPHYLOCOCCUS-AUREUS [J].
FUKAMI, M ;
NORLANDER, T ;
STIERNA, P ;
WESTRIN, KM ;
CARLSOO, B ;
NORD, CE .
AMERICAN JOURNAL OF RHINOLOGY, 1993, 7 (03) :125-132
[8]   EARLY MUCOSAL CHANGES IN EXPERIMENTAL SINUSITIS [J].
HINNI, ML ;
MCCAFFREY, TV ;
KASPERBAUER, JL .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1992, 107 (04) :537-548
[9]  
HSU J, IN PRESS AM J RHINOL
[10]   EXPERIMENTAL ACUTE SINUSITIS IN RABBITS - A BACTERIOLOGICAL AND HISTOLOGICAL STUDY [J].
JOHANSSON, P ;
KUMLIEN, J ;
CARLSOO, B ;
DRETTNER, B ;
NORD, CE .
ACTA OTO-LARYNGOLOGICA, 1988, 105 (3-4) :357-366