Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats

被引:200
作者
Brandon, CL
Marinelli, M
Baker, LK
White, FJ
机构
[1] Finch Univ Hlth Sci Chicago Med Sch, Dept Cellular & Mol Pharmacol, N Chicago, IL 60064 USA
[2] Finch Univ Hlth Sci Chicago Med Sch, Dept Cell Biol & Anat, N Chicago, IL 60064 USA
关键词
attention deficit hyperactivity disorder; self-administration; sensitization; Ritalin (R); substance abuse disorder; addiction;
D O I
10.1016/S0893-133X(01)00281-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Treatment of attention deficit hyperactivity disorder with the psychostimulant drug methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether repeated exposure to moderate doses of MP (5 and 10 mg/kg IP for 5 or 7 days) in adolescent rats increased reactivity to cocaine measured by motor responses (ambulations and rearing) to a cocaine challenge in adulthood. We later tested whether repeated exposure to a low dose of MP (2 mg/kg IP for 7 days) enhanced the psychomotor effects of cocaine, measured by different challenge doses (0-30 mg/kg) as well as to the reinforcing effects of cocaine, measured by self-administration of low-dose infusion (75 mug/kg, IV). We found that exposure to moderate doses of MP enhanced psychomotor responses to cocaine but exposure to a low dose only increased cocaine self-administration. These results suggest that adolescent exposure to low doses of MP in rats may increase the incentive value of low reinforcers, thereby rendering adult rats more susceptible to cocaine self-administration. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
引用
收藏
页码:651 / 661
页数:11
相关论文
共 71 条
[1]   Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder [J].
Biederman, J ;
Wilens, T ;
Mick, E ;
Spencer, T ;
Faraone, SV .
PEDIATRICS, 1999, 104 (02) :art. no.-e20
[2]  
BIEDERMAN J, 1995, AM J PSYCHIAT, V152, P1652
[3]   MOTOR VOCAL TICS AND COMPULSIVE BEHAVIORS ON STIMULANT-DRUGS - IS THERE A COMMON VULNERABILITY [J].
BORCHERDING, BG ;
KEYSOR, CS ;
RAPOPORT, JL ;
ELIA, J ;
AMASS, J .
PSYCHIATRY RESEARCH, 1990, 33 (01) :83-94
[4]   The influence of environment on the induction of sensitization to the psychomotor activating effects of intravenous cocaine in rats is dose-dependent [J].
Browman, KE ;
Badiani, A ;
Robinson, TE .
PSYCHOPHARMACOLOGY, 1998, 137 (01) :90-98
[5]   Controlled stimulant treatment of ADHD and comorbid Tourette's syndrome: Effects of stimulant and dose [J].
Castellanos, FX ;
Giedd, JN ;
Elia, J ;
Marsh, WL ;
Ritchie, GF ;
Hamburger, SD ;
Rapoport, JL .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (05) :589-596
[6]   Attention-deficit/hyperactivity disorder and substance use: Symptom pattern and drug choice [J].
Clure, C ;
Brady, KT ;
Saladin, ME ;
Johnson, D ;
Waid, R ;
Rittenbury, M .
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 1999, 25 (03) :441-448
[7]   Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum [J].
Crawford, CA ;
McDougall, SA ;
Meier, TL ;
Collins, RL ;
Watson, JB .
PSYCHOPHARMACOLOGY, 1998, 136 (01) :34-43
[8]   ADOLESCENT COCAINE ABUSE - ADDICTIVE POTENTIAL, BEHAVIORAL AND PSYCHIATRIC EFFECTS [J].
ESTROFF, TW ;
SCHWARTZ, RH ;
HOFFMANN, NG .
CLINICAL PEDIATRICS, 1989, 28 (12) :550-555
[9]   Susceptibility to amphetamine-induced locomotor sensitization is modulated by environmental stimuli [J].
Fraioli, S ;
Crombag, HS ;
Badiani, A ;
Robinson, TE .
NEUROPSYCHOPHARMACOLOGY, 1999, 20 (06) :533-541
[10]   Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats [J].
Garland, EJ .
JOURNAL OF PSYCHOPHARMACOLOGY, 1998, 12 (04) :385-395