Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma

被引：142

作者：

da Silva, EL

Piskula, MK

Yamamoto, N

Moon, JH

Terao, J

机构：

[1] Univ Tokushima, Sch Med, Dept Nutr, Okayama 700, Japan

[2] Univ Fed Santa Catarina, Ctr Ciencias Saude, BR-88040900 Florianopolis, SC, Brazil

[3] Inst Anim Reprod & Food Res, PL-10718 Olsztyn, Poland

[4] Takeda Food Prod Ltd, Itami, Hyogo 664, Japan

来源：

FEBS LETTERS | 1998年 / 430卷 / 03期

关键词：

flavonoid; quercetin; conjugated metabolite; antioxidant; lipid peroxidation;

D O I：

10.1016/S0014-5793(98)00709-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The oxidative susceptibility of plasma obtained from rats after intragastric administration of quercetin was studied to know whether or not quercetin acts as an in vivo antioxidant after metabolic conversion. Quercetin was raised in the rat blood plasma essentially as glucuronide and/or sulfate conjugates, The plasma obtained from rats after quercetin administration was more resistant against copper sulfate-induced lipid peroxidation than the control plasma on the basis of the accumulation of cholesteryl ester hydroperoxides and the consumption of alpha-tocopherol, The results strongly suggest that some conjugated metabolites of quercetin act as effective antioxidants when plasma is subject to metal ion-induced lipid peroxidation. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：405 / 408

页数：4

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