Recent advances in the genetics of autoimmune diseases

被引：13

作者：

Alarcon-Riquelme, Marta E. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH | 2007年 / 1110卷

关键词：

systemic lupus erythematosus; inflammatory bowel disease; type 1 diabetes mellitus; rheumatoid arthritis; linkage; genetic association; single nucleotide polymorphisms; chromosomes; copy number variation;

D O I：

10.1196/annals.1423.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases in general are complex genetic diseases where genes and environment interact in unknown ways. In recent years technologies have advanced our knowledge and new genes are being identified very rapidly. We can expect that most genes of major importance for the various autoimmune diseases will be discovered in the coming 5 years. The real challenge comes when we try to understand the mechanisms through which these genes confer disease susceptibility and how the interaction with environment takes place such that clinical expression of the disease results.

引用

页码：1 / 9

页数：9

共 53 条

[1] MAJOR HISTOCOMPATIBILITY COMPLEX GENES IN SYSTEMIC LUPUS-ERYTHEMATOSUS, SJOGRENS SYNDROME, AND POLYMYOSITIS [J].

ARNETT, FC ;

GOLDSTEIN, R ;

DUVIC, M ;

REVEILLE, JD .

AMERICAN JOURNAL OF MEDICINE, 1988, 85 (6A) :38-41

[2] HLA AND GENETIC PREDISPOSITION TO LUPUS-ERYTHEMATOSUS AND OTHER DERMATOLOGIC DISORDERS [J].

ARNETT, FC .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1985, 13 (03) :472-481

[3] Investigation of the SLC22A4 Gene (Associated With Rheumatoid Arthritis in a Japanese Population) in a United Kingdom Population of Rheumatoid Arthritis Patients [J].

Barton, Anne ;

Eyre, Stephen ;

Bowes, John ;

Ho, Pauline ;

John, Sally ;

Worthington, Jane .

ARTHRITIS AND RHEUMATISM, 2005, 52 (03) :752-758

[4] A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].

Begovich, AB ;

Carlton, VEH ;

Honigberg, LA ;

Schrodi, SJ ;

Chokkalingam, AP ;

Alexander, HC ;

Ardlie, KG ;

Huang, QQ ;

Smith, AM ;

Spoerke, JM ;

Conn, MT ;

Chang, M ;

Chang, SYP ;

Saiki, RK ;

Catanese, JJ ;

Leong, DU ;

Garcia, VE ;

McAllister, LB ;

Jeffery, DA ;

Lee, AT ;

Batliwalla, F ;

Remmers, E ;

Criswell, LA ;

Seldin, MF ;

Kastner, DL ;

Amos, CI ;

Sninsky, JJ ;

Gregersen, PK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337

[5] A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes [J].

Bottini, N ;

Musumeci, L ;

Alonso, A ;

Rahmouni, S ;

Nika, K ;

Rostamkhani, M ;

MacMurray, J ;

Meloni, GF ;

Lucarelli, P ;

Pellecchia, M ;

Eisenbarth, GS ;

Comings, D ;

Mustelin, T .

NATURE GENETICS, 2004, 36 (04) :337-338

[6] New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study [J].

Cornelis, F ;

Faure, S ;

Martinez, M ;

Prud'Homme, JF ;

Fritz, P ;

Dib, C ;

Alves, H ;

Barrera, P ;

De Vries, N ;

Balsa, A ;

Pascual-Salcedo, D ;

Maenaut, K ;

Westhovens, R ;

Migliorini, P ;

Tran, TH ;

Delaye, A ;

Prince, N ;

Lefevre, C ;

Thomas, G ;

Poirier, M ;

Soubigou, S ;

Alibert, O ;

Lasbleiz, S ;

Fouix, S ;

Bouchier, C ;

Lioté, F ;

Loste, MN ;

Lepage, V ;

Charron, D ;

Gyapay, G ;

Lopes-Vaz, A ;

Kuntz, D ;

Bardin, T ;

Weissenbach, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10746-10750

[7] Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis -: Evidence for genetic heterogeneity [J].

Dieudé, P ;

Petit, E ;

Cailleau-Moindrault, S ;

Osorio, J ;

Pierlot, C ;

Martinez, M ;

Fauré, S ;

Alibert, O ;

Lasbleiz, S ;

de Toma, C ;

Bardin, T ;

Prum, B ;

Cornélis, F .

ARTHRITIS AND RHEUMATISM, 2002, 46 (08) :2039-2044

[8] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].

Duerr, Richard H. ;

Taylor, Kent D. ;

Brant, Steven R. ;

Rioux, John D. ;

Silverberg, Mark S. ;

Daly, Mark J. ;

Steinhart, A. Hillary ;

Abraham, Clara ;

Regueiro, Miguel ;

Griffiths, Anne ;

Dassopoulos, Themistocles ;

Bitton, Alain ;

Yang, Huiying ;

Targan, Stephan ;

Datta, Lisa Wu ;

Kistner, Emily O. ;

Schumm, L. Philip ;

Lee, Annette T. ;

Gregersen, Peter K. ;

Barmada, M. Michael ;

Rotter, Jerome I. ;

Nicolae, Dan L. ;

Cho, Judy H. .

SCIENCE, 2006, 314 (5804) :1461-1463

[9] Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus [J].

Edberg, JC ;

Langefeld, CD ;

Wu, JM ;

Moser, KL ;

Kaufman, KM ;

Kelly, J ;

Bansal, V ;

Brown, WM ;

Salmon, JE ;

Rich, SS ;

Harley, JB ;

Kimberly, RP .

ARTHRITIS AND RHEUMATISM, 2002, 46 (08) :2132-2140

[10] Genome screening in human systemic lupus erythematosus: Results from a second Minnesota cohort and combined analyses of 187 sib-pair families [J].

Gaffney, PM ;

Ortmann, WA ;

Selby, SA ;

Shark, KB ;

Ockenden, TC ;

Rohlf, KE ;

Walgrave, NL ;

Boyum, WP ;

Malmgren, ML ;

Miller, ME ;

Kearns, GM ;

Messner, RP ;

King, RA ;

Rich, SS ;

Behrens, TW .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (02) :547-556

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