Asymmetric cyclopropanation of olefins with an in situ generated phenyliodonium ylide

被引：24

作者：

Müller, P ^{[1
]}

Ghanem, A ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

SYNLETT | 2003年 / 12期

关键词：

asymmetric catalysis; alkenes; carbenes; rhodium; ylides;

D O I：

10.1055/s-2003-41456

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for the in situ generation of the phenyliodonium ylide (2) derived from Meldrum's acid (1) and its Rh(II)catalyzed decomposition to afford an intermediate metallocarbene is described. In the presence of olefins, cyclopropanes are formed with yields and enantioselectivity comparable to that resulting from cyclopropanation with the isolated ylide 2.

引用

页码：1830 / 1833

页数：4

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