G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients

被引：15

作者：

Deng, H ^{[1
]}

Le, WD ^{[1
]}

Zhang, X ^{[1
]}

Pan, TH ^{[1
]}

Jankovic, J ^{[1
]}

机构：

[1] Baylor Coll Med, Parkinsons Dis Ctr & Movement Disorders Clin, Dept Neurol, Houston, TX 77030 USA

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2005年 / 111卷 / 06期

关键词：

G309D; W437OPA; PINK1; Caucasian; Parkinson's disease;

D O I：

10.1111/j.1600-0404.2005.00383.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective - To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD). Methods - We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients. Results - None of the 237 samples showed the G309D or W437OPA mutations. Conclusions - The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.

引用

页码：351 / 352

页数：2

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