Pretreatment Serum Anti-Mullerian Hormone Predicts Long-Term Ovarian Function and Bone Mass after Chemotherapy for Early Breast Cancer

被引:183
作者
Anderson, Richard A. [1 ,2 ]
Cameron, David A. [3 ,4 ]
机构
[1] Univ Edinburgh, Queens Med Res Inst, Div Reprod & Dev Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Univ Edinburgh, MRC, Human Reprod Sci Unit, Ctr Reprod Biol, Edinburgh EH16 4TJ, Midlothian, Scotland
[3] Western Gen Hosp, Edinburgh Breast Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[4] Univ Edinburgh, Western Gen Hosp, Canc Res Ctr, Edinburgh EH4 2XU, Midlothian, Scotland
基金
英国医学研究理事会;
关键词
PREMENOPAUSAL WOMEN; MINERAL DENSITY; ADJUVANT CHEMOTHERAPY; INHIBIN-B; ANTIMULLERIAN HORMONE; YOUNG-WOMEN; RESERVE; FAILURE; FERTILITY; MENOPAUSE;
D O I
10.1210/jc.2010-2582
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Administration of chemotherapy to premenopausal women shortens their reproductive lifespan by depleting nonrenewable oocytes. Preservation of fertility is a priority for many such women, and identification of women at risk of infertility is therefore important. However, age is the only patient characteristic currently recognized to be predictive of long-term ovarian function after chemotherapy. Objective: Our objective was to assess markers of ovarian reserve and age as long-term predictors of ovarian function after chemotherapy. Design and Setting: We conducted a prospective, longitudinal study at a university hospital and research institute. Patients: Patients included women who were premenopausal at the time of diagnosis of early breast cancer. Main Outcome Measures: Ovarian function was assessed at 5 yr follow-up in relation to pretreatment hormonal and ultrasound markers of ovarian reserve. Results: Forty-two women received (neo-) adjuvant chemotherapy. Continuing menses 4-5 yr after diagnosis closely reflected ovarian activity as assessed by a range of serum markers, including estradiol, inhibin B, FSH, and anti-Mullerian hormone (AMH). Pretreatment serum AMH, FSH, antral follicle count, and age predicted late ovarian activity by univariate analysis. However, only AMH was predictive in a multivariate logistic regression (odds ratio = 13.0; 95% confidence interval = 2.5-66.7); 0.71 ng/ml gave peak likelihood ratio of 7.0 with 54% sensitivity and 92% specificity. Bone mineral density fell over the 4-5 yr after diagnosis with greater loss in women with lower ovarian activity. Higher pretreatment AMH was associated with lower bone mineral density at both lumbar spine and hip at 5 yr (P < 0.02). Conclusion: Measurement of AMH at cancer diagnosis predicts long-term ovarian function after chemotherapy. Use of this in clinical practice may allow better prediction of chemotherapy-related risk to future fertility. (J Clin Endocrinol Metab 96: 1336-1343, 2011)
引用
收藏
页码:1336 / 1343
页数:8
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