Molecular biological access to the chemistry of unknown soil microbes: A new frontier for natural products

被引：1176

作者：

Handelsman, J

Rondon, MR

Brady, SF

Clardy, J

Goodman, RM

机构：

[1] Univ Wisconsin, Dept Plant Pathol, Madison, WI 53706 USA

[2] Cornell Univ, Baker Lab, Dept Chem & Biol Chem, Ithaca, NY 14853 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 10期

关键词：

D O I：

10.1016/S1074-5521(98)90108-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cultured soil microorganisms have provided a rich source of natural-product chemistry. Because only a tiny fraction of soil microbes from soil are readily cultured, soil might be the greatest untapped resource for novel chemistry. The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.

引用

收藏

页码：R245 / R249

页数：5

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