A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

被引：54

作者：

Asherson, P. ^{[1
]}

Zhou, K. ^{[1
]}

Anney, R. J. L. ^{[2
]}

Franke, B. ^{[3
,4
]}

Buitelaar, J. ^{[4
]}

Ebstein, R. ^{[5
]}

Gill, M. ^{[2
]}

Altink, M. ^{[4
]}

Arnold, R.

Boer, F. ^{[6
]}

Brookes, K. ^{[1
]}

Buschgens, C. ^{[4
]}

Butler, L. ^{[2
]}

Cambell, D. ^{[1
]}

Chen, W. ^{[1
]}

Christiansen, H. ^{[7
]}

Feldman, L.

Fleischman, K. ^{[1
]}

Fliers, E. ^{[4
]}

Howe-Forbes, R. ^{[1
]}

Goldfarb, A. ^{[5
]}

Heise, A. ^{[8
]}

Gabrieels, I. ^{[9
]}

Johansson, L. ^{[1
]}

Lubetzki, I. ^{[10
]}

Marco, R.

Medad, S. ^{[5
]}

Minderaa, R.

Mulas, F. ^{[11
]}

Mueller, U. ^{[12
]}

Mulligan, A. ^{[3
]}

Neale, B. ^{[1
]}

Rijsdijk, F. ^{[1
]}

Rabin, K. ^{[5
]}

Rommelse, N. ^{[13
]}

Sethna, V. ^{[1
]}

Sorohan, J. ^{[2
]}

Uebel, H.

Psychogiou, L.

Weeks, A. ^{[14
]}

Barrett, R. ^{[14
]}

Xu, X. ^{[1
]}

Banaschewski, T. ^{[8
]}

Sonuga-Barke, E. J. S. ^{[14
]}

Eisenberg, J. ^{[5
]}

Manor, I. ^{[5
]}

Miranda, A. ^{[11
]}

Oades, R. D. ^{[7
]}

Roeyers, H. ^{[9
]}

Rothenberger, A. ^{[8
]}

机构：

[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England

[2] St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland

[3] Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[4] Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands

[5] Geha Mental Hlth Ctr, ADHD Clin, Petah Tiqwa, Israel

[6] Amsterdam Med Ctr Bascule, Amsterdam, Netherlands

[7] Univ Clin Child Adolescent Psychiat, Amsterdam, Netherlands

[8] Univ Gottingen, Gottingen, Germany

[9] Univ Ghent, Dept Expt Clin Hlth Psychol, B-9000 Ghent, Belgium

[10] Shaare Zedek Med Ctr, Jerusalem, Israel

[11] Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain

[12] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Child & Adolescent Psychiat, NL-9713 AV Groningen, Netherlands

[13] Vrije Univ Amsterdam, Amsterdam, Netherlands

[14] Univ Southampton, Sch Psychol, Southampton, Hants, England

[15] SUNY Syracuse, Dept Psychiat & Neurosci & Physsiol, Syracuse, NY USA

来源：

MOLECULAR PSYCHIATRY | 2008年 / 13卷 / 05期

关键词：

ADHD; affected sib pairs; linkage;

D O I：

10.1038/sj.mp.4002140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.

引用

页码：514 / 521

页数：8

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